Dataset for clinical parameters and disease transcriptome networks associated with exposure to citalopram in zebrafish (Danio rerio) larvae.

ABSTRACT: Citalopram, a selective serotonin reuptake inhibitor (SSRI), is often detected in aquatic ecosystems. In this investigation, developing zebrafish were continuously exposed to one nominal concentration of either 0, 10, or 1000 µg/L citalopram for 7 days. Ribonucleic acids were then extracted from zebrafish for RNA-sequencing using the NovoSeq 6000 (Illumina). Clean reads were obtained following the removal of both the adapter and poly-N sequences. Alignment and differential gene expression analysis was conducted using programs HISAT2 and StringTie assembler. Data were converted to FPKM to quantify differentially expressed transcripts. Significant clinical subnetworks enriched following citalopram exposure included sympathetic nerve activity, blood pressure, vascular tone, and arterial press

SUBMITTER: Kazi KJ 

PROVIDER: S-EPMC11327532 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature