Synthesis of 2-aminothiazole sulfonamides as potent biological agents: Synthesis, structural investigations and docking studies.

ABSTRACT: A simplified synthetic approach involving sulfonylation followed by amino group alkylation produced new 2-aminothiazole derivatives. UV/Vis, infrared, and NMR spectroscopies confirmed their structures. Compounds 36, 22, 34, and 35 showed strong inhibition against Jack bean and Bacillus Pasteurii urease, with IC₅₀ values from 14.06 to 20.21 μM/mL. Compounds 20, 26, 21, 29, 30, 31, and 32 exhibited potent inhibitory effects against α-glucosidase and α-amylase, with IC₅₀ values between 20.34 and 37.20 μM/mL. Compounds 33, 26, and 27 demonstrated potent DPPH scavenging, with IC₅₀ values around 34.4-39.2 μM/mL. FMO analysis showed compounds 21, 22,

SUBMITTER: Khair-Ul-Bariyah S 

PROVIDER: S-EPMC11327602 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature