IDH2 mutation accelerates TPO-induced myelofibrosis with enhanced S100a8/a9 and NFκB signaling in vivo.

ABSTRACT:

Introduction

IDH2 mutation is an unfavorable prognostic factor in patients with primary myelofibrosis (PMF) but its effect on myelofibrosis (MF) remains largely unclear.

Methods

In this study, we aimed to elucidate the roles of IDH2 mutation in the development and progression of MF by transcriptomic and molecular techniques using the Idh2 ^R172K transgenic mice.

Results

We found that thrombopoietin (TPO)-overexpressed Idh2 ^R172K (Idh2 ^R172K + TPO) mice had accelerated progression to MF, compared with TPO-overexpressed Idh2-wild (WT + TPO) mice, showing activation of multiple inflammatory pathways, among which nuclear factor κB (NFκB) was the most significantly enhanced. Single-cell transcriptome

SUBMITTER: Lin CC 

PROVIDER: S-EPMC11327712 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature