The miRNAs 203a/210-3p/5001-5p regulate the androgen/androgen receptor/YAP-induced migration in prostate cancer cells.

ABSTRACT:

Background

Prostate cancer (PCa) patients with elevated level of androgen receptor (AR) correlate with higher metastatic incidence. Protein expression of AR and its target gene prostate-specific antigen (PSA) are elevated in metastatic prostate tumors as compared to organ-confined tumors. Androgen treatment or elevation of AR promotes metastasis of PCa in cell culture and murine model. However, under androgen depleted condition, AR suppressed cell mobility and invasiveness of PCa cells. Androgen deprivation therapy in PCa patients is associated with higher risk of cancer metastasis. We therefore investigated the dual roles of AR and miRNAs on PCa metastasis.

Methods

The PC-3^AR (PC-3 cells re-expressing AR) and LNCaP cells were used as PCa cell model. Transwell mig

SUBMITTER: Huo C 

PROVIDER: S-EPMC11327718 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature