HPV16 Genomes: In Silico Analysis of E6 and E7 Oncoproteins in 20 South American Variants.

ABSTRACT:

Background

Human papillomavirus (HPV) is the main risk factor for the development of squamous cell cervical cancer, and E6 oncoprotein and E7 oncoprotein are important components of the viral genome and its oncogenic potential. It is known that different viral variants of HPV16 have different pathology and impact on the development of neoplasia, although few studies have been performed on South American variants.

Objective

Therefore, the present study aimed to analyze in silico the genomic diversity of HPV16 in 20 complete genome variants of South America in the National Center for Biotechnology Information (NCBI) database.

Methods

We performed a descriptive study to characterize the polymorphic regions of the E6 and E7 genes in HPV16 variants, using software f

SUBMITTER: de Paula Filho MFF 

PROVIDER: S-EPMC11327806 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature