Relationship between epicardial adipose tissue and coronary atherosclerosis by CCTA in young adults (18-45).

ABSTRACT:

Objective

Epicardial adipose tissue (EAT) is implicated in the pathogenesis and progression of coronary artery disease (CAD). Limited data exists on the interplay between EAT and atherosclerosis in young individuals. Our study aims to explore the relationship between EAT and CAD in a young cohort.

Methods

All young (18-45 years) patients without prior CAD, referred for coronary computed tomography angiography (CCTA) from 2016 to 2022 were included. EAT volume and coronary artery calcium (CAC) were calculated from dedicated non-contrast scans. Coronary plaque presence, extent, and volume were quantified from CCTA. Multivariable logistic regression models for the presence of CAD, defined as any coronary atherosclerosis, were performed.

Results

Overall, 712 patients (39±

SUBMITTER: Filtz A 

PROVIDER: S-EPMC11327837 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature