The global burden and trend of Clostridioides difficile and its association with world antibiotic consumption, 1990-2019.

ABSTRACT:

Background

To estimate the global trends and disease burden of Clostridioides difficile infection (CDI) and its correlation with worldwide antibiotic consumption.

Methods

Clostridioides difficile infection and antibiotic consumption data were retrieved from the Global Burden of Disease 2019, ResistanceMap-AntibiocUse, Food and Drug Administration (FDA) Adverse Event Reporting System, and Global Antimicrobial Resistance and Use Surveillance System. Jointpoint regression and age-period-cohort model were developed to show the global trends and burden of CDI. Correlation tests were calculated to explore the relationship between CDI and antibiotics.

Results

Globally, CDI is the most significant one with a high-rocketing burden increase rate among 13 pathogens causing diarr

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11327847 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature