The causal relationships of granulocytes and melanoma skin cancer: A univariable and multivariable Mendelian randomization study.

ABSTRACT:

Background

Increasing evidence has revealed that granulocyte has a critical role in tumorigenesis and progression. In this study, Mendelian randomization (MR) analysis was utilized for estimating the causal association between neutrophil percentage and melanoma skin cancer, eosinophil percentage and melanoma skin cancer, basophil percentage and melanoma skin cancer, respectively.

Methods

The Genome-Wide Association Study (GWAS) ids for melanoma skin cancer, neutrophil percentage, eosinophil percentage and basophil percentage were derived from Integrative Epidemiology Unit (IEU) Open GWAS database. The univariable MR (UVMR) analysis was conducted to estimate the risk using MR-Egger, weighted median, inverse variance weighted (IVW). In addition, sensitivity analysis was conduc

SUBMITTER: Rui-Chang Z 

PROVIDER: S-EPMC11327865 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature