Exploring computational approaches to design mRNA Vaccine against vaccinia and Mpox viruses.

ABSTRACT:

Background

Messenger RNA (mRNA) vaccines emerged as a powerful tool in the fight against infections. Unlike traditional vaccines, this unique type of vaccine elicits robust and persistent innate and humoral immune response with a unique host cell-mediated pathogen gene expression and antigen presentation.

Methods

This offers a novel approach to combat poxviridae infections. From the genome of vaccinia and Mpox viruses, three key genes (E8L, E7R, and H3L) responsible for virus attachment and virulence were selected and employed for designing the candidate mRNA vaccine against vaccinia and Mpox viral infection. Various bioinformatics tools were employed to generate (B cell, CTL, and HTL) epitopes, of which 28 antigenic and immunogenic epitopes were selected and are linked to f

SUBMITTER: Oladipo EK 

PROVIDER: S-EPMC11328121 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature