The post-stroke young adult brain has limited capacity to re-express the gene expression patterns seen during early postnatal brain development.

ABSTRACT: The developmental origins of the brain's response to injury can play an important role in recovery after a brain lesion. In this study, we investigated whether the ischemic young adult brain can re-express brain plasticity genes that were active during early postnatal development. Differentially expressed genes in the cortex of juvenile post-natal day 3 and the peri-infarcted cortical areas of young, 3-month-old post-stroke rats were identified using fixed-effects modeling within an empirical Bayes framework through condition-specific comparison. To further analyze potential biological processes, upregulated and downregulated genes were assessed for enrichment using GSEA software. The genes showing the highest expression changes were subsequently verified through RT-PCR. Our findings indic

SUBMITTER: Ruscu M 

PROVIDER: S-EPMC11328347 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature