Association between kidney function and Parkinson's disease risk: a prospective study from the UK Biobank.

ABSTRACT:

Background

Parkinson's disease (PD) is a neurodegenerative influenced by various clinical factors. The potential relationship between renal function and the risk of PD remains poorly understood. This study aims to explore the association between kidney function and the risk of developing PD.

Methods

A population-based cohort study was conducted using data from 400,571 UK Biobank participants. Renal function was assessed using the estimated glomerular filtration rate (eGFR), calculated from serum creatinine and cystatin C levels. The association between eGFR levels and PD risk was evaluated using univariate and multivariate Cox regression analyses, Restricted Cubic Spline (RCS) analysis, and Kaplan-Meier analysis. Additionally, a clinical prediction model was developed and it

SUBMITTER: Peng H 

PROVIDER: S-EPMC11328353 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature