Microbial assimilatory sulfate reduction-mediated H₂S: an overlooked role in Crohn's disease development.

ABSTRACT:

Background

H₂S imbalances in the intestinal tract trigger Crohn's disease (CD), a chronic inflammatory gastrointestinal disorder characterized by microbiota dysbiosis and barrier dysfunction. However, a comprehensive understanding of H₂S generation in the gut, and the contributions of both microbiota and host to systemic H₂S levels in CD, remain to be elucidated. This investigation aimed to enhance comprehension regarding the sulfidogenic potential of both the human host and the gut microbiota.

Results

Our analysis of a treatment-naive CD cohorts' fecal metagenomic and biopsy metatranscriptomic data revealed reduced expression of host endogenous H₂S generation genes alongside increased abundance of microbial exogenous H₂

SUBMITTER: Luo W 

PROVIDER: S-EPMC11328384 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature