Visualizing and diagnosing spillover within randomized concurrent controlled trials through the application of diagnostic test assessment methods.

ABSTRACT:

Background

Spillover of effect, whether positive or negative, from intervention to control group patients invalidates the Stable Unit Treatment Variable Assumption (SUTVA). SUTVA is critical to valid causal inference from randomized concurrent controlled trials (RCCT). Spillover of infection prevention is an important population level effect mediating herd immunity. This herd effect, being additional to any individual level effect, is subsumed within the overall effect size (ES) estimate derived by contrast-based techniques from RCCT's. This herd effect would manifest only as increased dispersion among the control group infection incidence rates above background.

Methods and results

The objective here is to explore aspects of spillover and how this might be visualized and di

SUBMITTER: Hurley JC 

PROVIDER: S-EPMC11328391 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature