The compositional and functional imbalance of the gut microbiota in CKD linked to disease patterns.

ABSTRACT:

Background

The prevalence of chronic kidney disease (CKD) is on the rise, posing a significant public health challenge. Although gut microbiome dysbiosis has been implicated in the impairment of kidney functions, the existence of pathological subtypes-linked differences remains largely unknown. We aimed to characterize the intestinal microbiota in patients with membranous nephropathy (MN), IgA nephropathy (IgAN), minimal change disease (MCD), and ischemic renal injury (IRI) in order to investigate the intricate relationship between intestinal microbiota and CKD across different subtypes.

Methods

We conducted a cross-sectional study involving 94 patients with various pathological patterns of CKD and 54 healthy controls (HCs). The clinical parameters were collected, and stool

SUBMITTER: Li J 

PROVIDER: S-EPMC11328458 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature