Clinicopathologic Features of IgG4-Related Kidney Disease.

ABSTRACT:

Introduction

IgG4-related disease (IgG4-RD) is a systemic immune-mediated disease that can involve nearly any organ. IgG4-RD can affect the kidney in different disease patterns, collectively referred to as IgG4-related kidney disease (IgG4-RKD).

Methods

We conducted a tissue-based cohort study with clinicopathological correlation in 125 patients with IgG4-RKD.

Results

The mean age at biopsy (n = 120) or nephrectomy (n = 5) was 63 years; 80% were male. One hundred eighteen patients (94%) had IgG4-related tubulointerstitial nephritis (IgG4-TIN); 20 patients (16%) had IgG4-related membranous glomerulonephritis (IgG4-MGN; 13 with concurrent IgG4-TIN). The primary clinical indication for biopsy/nephrectomy was acute or chronic renal failure in 78%, proteinuri

SUBMITTER: Buglioni A 

PROVIDER: S-EPMC11328570 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature