IL-22 promotes mucin-type O-glycosylation and MATH1⁺ cell-mediated amelioration of intestinal inflammation.

ABSTRACT: The interleukin (IL)-22 cytokine can be protective or inflammatory in the intestine. It is unclear if IL-22 receptor (IL-22Ra1)-mediated protection involves a specific type of intestinal epithelial cell (IEC). By using a range of IEC type-specific Il22Ra1 conditional knockout mice and a dextran sulfate sodium (DSS) colitis model, we demonstrate that IL-22Ra1 signaling in MATH1⁺ cells (goblet and progenitor cells) is essential for maintaining the mucosal barrier and intestinal tissue regeneration. The IL-22Ra1 signaling in IECs promotes mucin core-2 O-glycan extension and induces beta-1,3-galactosyltransferase 5 (B3GALT5) expression in the colon. Adenovirus-mediated expression of B3galt5 is sufficient to rescue Il22Ra1^IEC mice from DSS colitis. Additionally, we observe

SUBMITTER: Singh A 

PROVIDER: S-EPMC11328608 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature