Untangling the relationship between smoking and systemic sclerosis: an analysis of the EUSTAR cohort.

ABSTRACT:

Objectives

To untangle the association between smoking and systemic sclerosis (SSc).

Methods

In the European Scleroderma Trials and Research cohort, the autoantibody status was compared between ever-smokers and never-smokers. Time until disease progression was assessed using Kaplan-Meier curves. Cox models were built to investigate the influence of smoking over 15 years of follow-up. All analyses were performed for the total cohort and stratified for sex and for positivity of anti-centromere (ACA) and anti-topoisomerase antibodies (ATA).

Results

Overall, 12 314 patients were included in the study. Of these, 10 393 were women (84%), 4637 were ACA-positive (38%), 3919 were ATA-positive (32%) and 4271 (35%) were ever-smokers. In men, but not in women, smoking was associa

SUBMITTER: Ciaffi J 

PROVIDER: S-EPMC11328649 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature