Risk cycling in diabetes and autism spectrum disorder: a bidirectional Mendelian randomization study.

ABSTRACT: The relationship between diabetes mellitus (DM) and autism spectrum disorder (ASD) remains controversial. This study aimed to analyze the causal relationship between different types of DM and ASD by bidirectional Mendelian randomization (MR). Single nucleotide polymorphisms for type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), gestational diabetes mellitus (GDM), and ASD were obtained from genome-wide association studies. Subsequently, inverse variance weighted, MR-Egger, and weighted median were used to test the exposure-outcome causality. Finally, MR-Egger's intercept, Cochran's Q, and leave-one-out method were used to assess horizontal pleiotropy, heterogeneity, and sensitivity of the results, respectively. The positive analysis showed that T2DM was associated with an in

SUBMITTER: Yu Y 

PROVIDER: S-EPMC11328693 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature