Homocysteine Metabolism, Subclinical Myocardial Injury, and Cardiovascular Mortality in the General Population.

ABSTRACT:

Background

Homocysteine (Hcy) is a recognized cardiovascular disease (CVD) risk factor linked with atherosclerosis. However, the association between Hcy and myocardial injury is little known.

Objectives

This study aimed to examine the associations between Hcy metabolism, subclinical myocardial injury, and cardiovascular mortality.

Methods

We included 10,871 participants without diagnosed CVD. Generalized linear regression was used to investigate the relationship between Hcy-related indicators (plasma total Hcy [tHcy], vitamin B₁₂, and folate) and myocardial injury biomarkers (high-sensitivity troponin T [hs-cTnT], high-sensitivity troponin I [hs-cTnI] measured using 3 assays [Abbott, Siemens, and Ortho], and N-terminal pro-B-type natriuretic peptide

SUBMITTER: Tan X 

PROVIDER: S-EPMC11328767 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature