Association between hypothyroidism and nephrotic syndrome: a bidirectional two-sample Mendelian randomization analysis.

ABSTRACT:

Background

There is a close clinical association between hypothyroidism and nephrotic syndrome (NS) was close, but whether there is genetic causality between the two is not known.

Objective

Using pooled data from a genome-wide association study (GWAS), the association between hypothyroidism and NS was explored via Mendelian randomization (MR) analysis.

Methods

Single-nucleotide polymorphisms (SNPs) associated with hypothyroidism (or NS) were screened as genetic instrumental variables (IVs) from pooled GWAS data, and inverse-variance weighting (IVW) was used for the main analysis to estimate causal effects, with MR-Egger, weighted median, and weighted mode used as complementary methods. Sensitivity analyses, including Cochran's Q test, MR-Egger intercept, MR-PRE

SUBMITTER: Liu C 

PROVIDER: S-EPMC11328803 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature