Damage-Induced Senescent Immune Cells Regulate Regeneration of the Zebrafish Retina.

ABSTRACT: Zebrafish spontaneously regenerate their retinas in response to damage through the action of Müller glia (MG). Even though MG are conserved in higher vertebrates, the capacity to regenerate retinal damage is lost. Recent work has focused on the regulation of inflammation during tissue regeneration, with temporal roles for macrophages and microglia. Senescent cells that have withdrawn from the cell cycle have mostly been implicated in aging but are still metabolically active, releasing a variety of signaling molecules as part of the senescence-associated secretory phenotype. Here, we discover that in response to retinal damage, a subset of cells expressing markers of microglia/macrophages also express markers of senescence. These cells display a temporal pattern of appearance and clearance

SUBMITTER: Konar GJ 

PROVIDER: S-EPMC11328971 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature