Instability in Computational Models of Vascular Smooth Muscle Cell Contraction.

ABSTRACT:

Purpose

Through their contractile and synthetic capacity, vascular smooth muscle cells (VSMCs) can regulate the stiffness and resistance of the circulation. To model the contraction of blood vessels, an active stress component can be added to the (passive) Cauchy stress tensor. Different constitutive formulations have been proposed to describe this active stress component. Notably, however, measuring biomechanical behaviour of contracted blood vessels ex vivo presents several experimental challenges, which complicate the acquisition of comprehensive datasets to inform complex active stress models. In this work, we examine formulations for use with limited experimental contraction data as well as those developed to capture more comprehensive datasets.

Methods

First, we prove

SUBMITTER: Giudici A 

PROVIDER: S-EPMC11329416 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature