GALNT2 expression is associated with glucose control and serum metabolites in patients with type 2 diabetes.

ABSTRACT:

Aims

Aim of this study was to investigate in type 2 diabetes whether expression level of GALNT2, a positive modulator of insulin sensitivity, is associated with a metabolic signature.

Methods

Five different metabolite families, including acylcarnitines, aminoacids, biogenic amines, phospholipids and sphingolipids were investigated in fasting serum of 70 patients with type 2 diabetes, by targeted metabolomics. GALNT2 expression levels were measured in peripheral white blood cells by RT-PCR. The association between GALNT2 expression and serum metabolites was assessed using false discovery rate followed by stepwise selection and, finally, multivariate model including several clinical parameters as confounders. The association between GALNT2 expression and the same clinical para

SUBMITTER: Trischitta V 

PROVIDER: S-EPMC11329529 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature