Dataset Information

Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective.

ABSTRACT:

Purpose of review

To discuss the potential biological mechanisms between vitamin D and toxic metals and summarize epidemiological studies examining this association in pregnant women.

Recent findings

We identified four plausible mechanisms whereby vitamin D and toxic metals may interact: nephrotoxicity, intestinal absorption of metals, endocrine disruption, and oxidative stress. Few studies have examined the association between vitamin D and toxic metals in pregnant women. North American studies suggest that higher vitamin D status early in pregnancy are associated with lower blood metals later in pregnancy. However, a trial of vitamin D supplementation in a pregnant population, with higher metal exposures and lower overall nutritional status, does not corroborate these findings.

Summary

Given ubiquitous exposure to many toxic metals, nutritional intervention could be a means for prevention of adverse outcomes. Future prospective studies are needed to establish a causal relationship and clarify the directionality of vitamin D and metals.

Supplementary information

The online version contains supplementary material available at 10.1007/s40471-024-00348-0.

SUBMITTER: Fisher M

PROVIDER: S-EPMC11329583 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Publications

Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective.

Fisher Mandy M Weiler Hope A HA Kuiper Jordan R JR Borghese Michael M Buckley Jessie P JP Shutt Robin R Ashley-Martin Jillian J Subramanian Anita A Arbuckle Tye E TE Potter Beth K BK Little Julian J Morisset Anne-Sophie AS Jukic Anne Marie AM

Current epidemiology reports 20240620 3

<h4>Purpose of review</h4>To discuss the potential biological mechanisms between vitamin D and toxic metals and summarize epidemiological studies examining this association in pregnant women.<h4>Recent findings</h4>We identified four plausible mechanisms whereby vitamin D and toxic metals may interact: nephrotoxicity, intestinal absorption of metals, endocrine disruption, and oxidative stress. Few studies have examined the association between vitamin D and toxic metals in pregnant women. North A ...[more]

PMID: 39156920

Similar Datasets

Project description:Background/objectivesLow-level, in-utero exposure to toxic metals such as lead (Pb) and mercury (Hg) is widespread in the US and worldwide; and, individually, was found to be obesogenic in children. To address the literature gaps on the health effects of co-exposure to low-level toxic metals and the lack of intervention strategy, we aimed to investigate the association between in-utero co-exposure to Hg, Pb, cadmium (Cd) and childhood overweight or obesity (OWO) and whether adequate maternal micronutrients (selenium (Se) and folate) can be protective.Subjects/methodsThis study included 1442 mother-child pairs from the Boston Birth Cohort, a predominantly urban, low-income, Black, and Hispanic population, who were enrolled at birth and followed prospectively up to age 15 years. Bayesian kernel machine regression (BKMR) was applied to estimate individual and joint effects of exposures to metals and micronutrients on childhood OWO while adjusting for pertinent covariables. Stratified analyses by maternal OWO and micronutrient status were performed to identify sensitive subgroups.ResultsIn this sample of understudied US children, low-level in-utero co-exposure to Hg, Pb, and Cd was widespread. Besides individual positive associations of maternal Hg and Pb exposure with offspring OWO, BKMR clearly indicated a positive dose-response association between in-utero co-exposure to the three toxic metals and childhood OWO. Notably, the metal mixture-OWO association was more pronounced in children born to mothers with OWO; and in such a setting, the association was greatly attenuated if mothers had higher Se and folate levels.ConclusionsIn this prospective cohort of US children at high-risk of toxic metal exposure and OWO, we demonstrated that among children born to mothers with OWO, low-level in-utero co-exposure to Hg, Pb, and Cd increased the risk of childhood OWO; and that adequate maternal Se and folate levels mitigated the risk of childhood OWO.Clinical trial registry number and website where it was obtainedNCT03228875.

Dataset Information

Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective.

Purpose of review

Recent findings

Summary

Supplementary information

Publications

Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective.

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