Where Top-Down Meets Bottom-Up: Cell-Type Specific Connectivity Map of the Whisker System.

ABSTRACT: Sensorimotor computation integrates bottom-up world state information with top-down knowledge and task goals to form action plans. In the rodent whisker system, a prime model of active sensing, evidence shows neuromodulatory neurotransmitters shape whisker control, affecting whisking frequency and amplitude. Since neuromodulatory neurotransmitters are mostly released from subcortical nuclei and have long-range projections that reach the rest of the central nervous system, mapping the circuits of top-down neuromodulatory control of sensorimotor nuclei will help to systematically address the mechanisms of active sensing. Therefore, we developed a neuroinformatic target discovery pipeline to mine the Allen Institute's Mouse Brain Connectivity Atlas. Using network connectivity analysis, we ide

SUBMITTER: Rault N 

PROVIDER: S-EPMC11329691 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature