Ontology highlight
ABSTRACT:
SUBMITTER: Cao S
PROVIDER: S-EPMC11329713 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Cao Shiyang S Wang Tong T Ren Yifan Y Wu Gengshan G Zhang Yuan Y Tan Yafang Y Zhou Yazhou Y Chen Hongyan H Zhang Yu Y Song Yajun Y Yang Ruifu R Du Zongmin Z
Nature communications 20240816 1
Post-translational addition of O-linked N-acetylglucosamine (O-GlcNAc) to proteins is commonly associated with a variety of stress responses and cellular processes in eukaryotes, but its potential roles in bacteria are unclear. Here, we show that protein HmwC acts as an O-GlcNAc transferase (OGT) responsible for O-GlcNAcylation of multiple proteins in Yersinia pestis, a flea-borne pathogen responsible for plague. We identify 64 O-GlcNAcylated proteins (comprising 65 sites) with differential abun ...[more]