Focal seizures induce spatiotemporally organized spiking activity in the human cortex.

ABSTRACT: Epileptic seizures are debilitating because of the clinical symptoms they produce. These symptoms, in turn, may stem directly from disruptions in neural coding. Recent evidence has suggested that the specific temporal order, or sequence, of spiking across a population of cortical neurons may encode information. Here, we investigate how seizures disrupt neuronal spiking sequences in the human brain by recording multi-unit activity from the cerebral cortex in five male participants undergoing monitoring for seizures. We find that pathological discharges during seizures are associated with bursts of spiking activity across a population of cortical neurons. These bursts are organized into highly consistent and stereotyped temporal sequences. As the seizure evolves, spiking sequences diverge fr

SUBMITTER: Diamond JM 

PROVIDER: S-EPMC11329741 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature