Intestinal microbiology and urinary tract infection associated risk in long-term aged care residents.

ABSTRACT:

Background

Urinary tract infections (UTI) are the most frequently diagnosed infection in residents of long-term care and are a major risk factor for urosepsis, hospitalisation, and death. Translocation of gut pathobionts into the urinary tract is the presumed cause of most UTIs. While specific gut microbiota characteristics have been linked to UTI risk in younger adults, their relevance in aged care residents remains uncertain.

Methods

The faecal microbiome was assessed in 54 long-term aged care residents with a history of UTIs and 69 residents without a UTI history. Further comparisons were made to microbiome characteristics in 20 younger adults without UTIs. Microbiome characteristics were examined in relation to prior and subsequent UTIs, as well as antibiotic therapy.

SUBMITTER: Miller SJ 

PROVIDER: S-EPMC11329762 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature