Mapping the structure-function relationship along macroscale gradients in the human brain.

ABSTRACT: Functional coactivation between human brain regions is partly explained by white matter connections; however, how the structure-function relationship varies by function remains unclear. Here, we reference large data repositories to compute maps of structure-function correspondence across hundreds of specific functions and brain regions. We use natural language processing to accurately predict structure-function correspondence for specific functions and to identify macroscale gradients across the brain that correlate with structure-function correspondence as well as cortical thickness. Our findings suggest structure-function correspondence unfolds along a sensory-fugal organizational axis, with higher correspondence in primary sensory and motor cortex for perceptual and motor functions, and

SUBMITTER: Collins E 

PROVIDER: S-EPMC11329792 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature