Suvorexant for Reduction of Delirium in Older Adults After Hospitalization: A Randomized Clinical Trial.

ABSTRACT:

Importance

Delirium is common among older hospitalized adults. In addition to presenting immediate management issues, delirium can increase the long-term risk of dementia, institutionalization, and mortality. Delirium is associated with disrupted sleep, and prior studies suggest that some specific sleep-promoting agents may reduce delirium.

Objective

To evaluate the orexin receptor antagonist suvorexant for reducing delirium in older adults at high risk for delirium after hospitalization.

Design, setting, and participants

This double-blind, placebo-controlled, phase 3 randomized clinical trial was conducted at 50 hospitals in Japan between October 22, 2020, and December 23, 2022. The study population included Japanese adults aged 65 to 90 years who were at high risk f

SUBMITTER: Hatta K 

PROVIDER: S-EPMC11329875 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature