Diagnostic value of serum vascular endothelial growth factor-D in Korean patients with lymphangioleiomyomatosis.

ABSTRACT:

Background

Lymphangioleiomyomatosis (LAM) is a rare multisystemic disorder characterized by the proliferation of abnormal smooth muscle-like cells. Although serum vascular endothelial growth factor-D (VEGF-D) is currently used as a diagnostic biomarker for LAM, its diagnostic value in Korean patients is unclear.

Objectives

To evaluate the diagnostic value of serum VEGF-D for LAM in Korean patients.

Design

A multicenter prospective cohort study.

Methods

Serum samples were prospectively collected from five medical institutions, from patients with LAM (n = 40) and controls (n = 24; healthy participants = 3, other cystic lung diseases = 13, idiopathic pulmonary fibrosis = 4, idiopathic nonspecific interstitial pneumonia = 4). Serum VEGF-D levels were

SUBMITTER: Yoon HY 

PROVIDER: S-EPMC11329922 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature