Salidroside enhances NO bioavailability and modulates arginine metabolism to alleviate pulmonary arterial hypertension.

ABSTRACT:

Background

Salidroside (SAL), derived from Rhodiola, shows protective effects in pulmonary arterial hypertension (PAH) models, but its mechanisms are not fully elucidated.

Objectives

Investigate the therapeutic effects and the mechanism of SAL on PAH.

Methods

Monocrotaline was used to establish a PAH rat model. SAL's impact on oxidative stress and inflammatory responses in lung tissues was analyzed using immunohistochemistry, ELISA, and Western blot. Untargeted metabolomics explored SAL's metabolic regulatory mechanisms.

Results

SAL significantly reduced mean pulmonary artery pressure, right ventricular hypertrophy, collagen deposition, and fibrosis in the PAH rats. It enhanced antioxidant enzyme levels, reduced inflammatory cytokines, and improved NO bioavaila

SUBMITTER: Li J 

PROVIDER: S-EPMC11330049 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature