Clinical performance and utility: A microsimulation model to inform the design of screening trials for a multi-cancer early detection test.

ABSTRACT:

Objectives

Designing cancer screening trials for multi-cancer early detection (MCED) tests presents a significant methodology challenge, as natural histories of cell-free DNA-shedding cancers are not yet known. A microsimulation model was developed to project the performance and utility of an MCED test in cancer screening trials.

Methods

Individual natural history of preclinical progression through cancer stages for 23 cancer classes was simulated by a stage-transition model under a broad range of cancer latency parameters. Cancer incidences and stage distributions at clinical presentation in simulated trials were set to match the data from Surveillance, Epidemiology, and End Results program. One or multiple rounds of annual screening using a targeted methylation-based MCED

SUBMITTER: Dai JY 

PROVIDER: S-EPMC11330083 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature