Multiple valence states of Fe boosting SERS activity of Fe₃O₄ nanoparticles and enabling effective SERS-MRI bimodal cancer imaging.

ABSTRACT: Developing novel nanoparticle-based bioprobes utilized in clinical settings with imaging resolutions ranging from cell to tissue levels is a major challenge for tumor diagnosis and treatment. Herein, an optimized strategy for designing a Fe₃O₄-based bioprobe for dual-modal cancer imaging based on surface-enhanced Raman scattering (SERS) and magnetic resonance imaging (MRI) is introduced. Excellent SERS activity of ultrasmall Fe₃O₄ nanoparticles (NPs) was discovered, and a 5 × 10^-9 M limit of detection for crystal violet molecules was successfully obtained. The high-efficiency interfacial photon-induced charge transfer in Fe₃O₄ NPs was promoted by multiple electronic energy levels ascribed to the multiple valence s

SUBMITTER: Lin J 

PROVIDER: S-EPMC11330100 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature