A pharmacokinetic framework describing antibiotic adsorption to cardiopulmonary bypass devices.

ABSTRACT: Cardiopulmonary bypass (CPB) can alter pharmacokinetic (PK) parameters and the drug may adsorb to the CPB device, altering exposure. Cefazolin is a beta-lactam antibiotic used for antimicrobial prophylaxis during cardiac surgery supported by CPB. Adsorption of cefazolin could result in therapeutic failure. An ex vivo study was undertaken using CPB devices primed and then dosed with cefazolin and samples were obtained over 1 hour of recirculation. Twelve experimental runs were conducted using different CPB device sizes (neonate, infant, child, and adult), device coatings (Xcoating™, Rheoparin®, PH.I.S.I.O), and priming solutions. The time course of saturable binding, using B_max (binding capacity), K_d (dissociation constant), and T2_off (half-time of dissociat

SUBMITTER: O'Hanlon CJ 

PROVIDER: S-EPMC11330180 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature