DRD4 gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease.

ABSTRACT: Impulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors. In this retrospective study, we analyzed a cohort of Parkinson's disease patients treated with dopamine agonists and investigated the influence of the dopamine D4 receptor gene polymorphism, DRD4 7R+, which is linked to psychiatric disorders, impulsive traits, and addictive behaviors. We found that DRD4 7R+ is a significant genetic risk factor associated with the severity of ICD.

SUBMITTER: Torres V 

PROVIDER: S-EPMC11330210 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature