Clinical utility of diffusion MRI-derived measures of cortical microstructure in a real-world memory clinic setting.

ABSTRACT:

Objective

To investigate cortical microstructural measures from diffusion MRI as "neurodegeneration" markers that could improve prognostic accuracy in mild cognitive impairment (MCI).

Methods

The prognostic power of Amyloid/Tau/Neurodegeneration (ATN) biomarkers to predict progression from MCI to AD or non-AD dementia was investigated. Ninety patients underwent clinical evaluation (follow-up interval 32 ± 18 months), lumbar puncture, and MRI. Participants were grouped by clinical stage and cerebrospinal fluid Amyloid and Tau status. T1-structural and diffusion MRI scans were analyzed to calculate diffusion metrics related to cortical columnar structure (AngleR, ParlPD, PerpPD⁺), cortical mean diffusivity, and fractional anisotropy. Statistical tests were corrected

SUBMITTER: Torso M 

PROVIDER: S-EPMC11330221 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature