Associations of renin-angiotensin system inhibitor use with brain insulin signaling and neuropathology.

ABSTRACT:

Objective

To examine the associations of renin-angiotensin system (RAS) inhibitor use with postmortem brain insulin signaling and neuropathology.

Methods

Among Religious Orders Study participants, 150 deceased and autopsied older individuals (75 with diabetes matched to 75 without by age at death, sex, and education) had measurements of insulin receptor substrate-1 (IRS-1) and RAC-alpha serine/threonine protein kinase (AKT1) collected in the prefrontal cortex using ELISA and immunohistochemistry. Alzheimer's disease (AD), brain infarcts, and cerebral vessel pathology data were assessed by systematic neuropathologic evaluations. RAS inhibitor use was determined based on visual inspection of medication containers during study visits. The associations of RAS inhibitor use with

SUBMITTER: Tong H 

PROVIDER: S-EPMC11330222 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature