Altered brain perfusion and oxygen levels relate to sleepiness and attention in post-COVID syndrome.

ABSTRACT:

Objective

Persisting neurological symptoms after COVID-19 affect up to 10% of patients and can manifest in fatigue and cognitive complaints. Based on recent evidence, we evaluated whether cerebral hemodynamic changes contribute to post-COVID syndrome (PCS).

Methods

Using resting-state functional magnetic resonance imaging, we investigated brain perfusion and oxygen level estimates in 47 patients (44.4 ± 11.6 years; F:M = 38:9) and 47 individually matched healthy control participants. Group differences were calculated using two-sample t-tests. Multivariable linear regression was used for associations of each regional perfusion and oxygen level measure with cognition and sleepiness measures. Exploratory hazard ratios were calculated for each brain metric with clinical measures

SUBMITTER: Chien C 

PROVIDER: S-EPMC11330224 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature