Dose-exposure-efficacy response of intravenous immunoglobulin G 10% in multifocal motor neuropathy.

ABSTRACT:

Objective

Multifocal motor neuropathy is a rare chronic immune-mediated neuropathy with impaired grip strength representing a common symptom. While intravenous immunoglobulin G is an effective treatment for the disease, significant variation in treatment response has been observed but not well understood. This analysis characterized dose-exposure-response relationships in multifocal motor neuropathy, using grip strength as a clinical efficacy measure.

Methods

Serum immunoglobulin G trough concentrations and grip strength data for the more affected hand from a Phase 3, randomized, double-blind, placebo-controlled, crossover trial of intravenous immunoglobulin 10% in 44 patients with multifocal motor neuropathy (NCT00666263) were used to develop a population pharmacokinetic-ph

SUBMITTER: Li Z 

PROVIDER: S-EPMC11330225 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature