Dimensions of muddy brown granular casts in patients with acute tubular injury.

ABSTRACT:

Background

The presence of "muddy" brown granular casts (MBGC) in the urine sediment is pathognomonic for acute tubular injury (ATI). Although MBGC have been noted for years, there are no reports regarding their length nor width. The objective of this study was to measure MBGC using images obtained by light microscopy and investigate associations with clinically relevant parameters.

Methods

Patients with diagnosis of ATI as evidenced by visualization of abundant MBGC (>30% low power fields) were sampled. Bright-field images were measured using ImageJ. Twenty-five patients were included: 44% women; median age 64 yrs; 52% white, 36% black. Mean MBGC width (n = 350) was 34.4 ± 13.1 µm (range: 9 to 110 µm).

Results

Mean MBGC length was 98.7 ± 42.7 µm (range: 33 to 317 µm)

SUBMITTER: Antley MH 

PROVIDER: S-EPMC11330370 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature