Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta.

ABSTRACT: Converging evidence indicates that extra-embryonic yolk sac is the source of both macrophages and endothelial cells in adult mouse tissues. Prevailing views are that these embryonically derived cells are maintained after birth by proliferative self-renewal in their differentiated states. Here we identify clonogenic endothelial-macrophage (EndoMac) progenitor cells in the adventitia of embryonic and postnatal mouse aorta, that are independent of Flt3-mediated bone marrow hematopoiesis and derive from an early embryonic CX₃CR1⁺ and CSF1R⁺ source. These bipotent progenitors are proliferative and vasculogenic, contributing to adventitial neovascularization and formation of perfused blood vessels after transfer into ischemic tissue. We establish a regulatory rol

SUBMITTER: Williamson AE 

PROVIDER: S-EPMC11330468 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature