Structure and dimerization properties of the plant-specific copper chaperone CCH.

ABSTRACT: Copper chaperones of the ATX1 family are found in a wide range of organisms where these essential soluble carriers strictly control the transport of monovalent copper across the cytoplasm to various targets in diverse cellular compartments thereby preventing detrimental radical formation catalyzed by the free metal ion. Notably, the ATX1 family in plants contains two distinct forms of the cellular copper carrier. In addition to ATX1 having orthologs in other species, they also contain the copper chaperone CCH. The latter features an extra C-terminal extension whose function is still unknown. The secondary structure of this extension was predicted to be disordered in previous studies, although this has not been experimentally confirmed. Solution NMR studies on purified CCH presented in this

SUBMITTER: Dluhosch D 

PROVIDER: S-EPMC11330527 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature