Effects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress.

ABSTRACT: Hormonal imbalance during pregnancy is a risk factor for neuropsychiatric impairment in the offspring. It has been suggested that hypothyroidism leads to dysfunction of cortical GABAergic interneurons and inhibitory system development that in turn underlies impairment of the central nervous system. Here we investigated how gestational hypothyroidism affected offspring GABAergic system development as well as redox regulation parameters, because of previous links identified between the two. Experimental Gestational Hypothyroidism (EGH) was induced in CD-1 mice with 0.02% methimazole (MMI) in drinking water from embryonic day 9 (E9) until tissue collection at embryonic day 14 (E14) or E18. We examined GABAergic cell distribution and inhibitory system development gene expression as well as red

SUBMITTER: da Cunha Menezes E 

PROVIDER: S-EPMC11330572 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature