Pitavastatin attenuates hypercholesterolemia-induced decline in serotonin transporter availability.

ABSTRACT:

Introduction

Hypercholesterolemia is associated with increased inflammation and impaired serotonin neurotransmission, potentially contributing to depressive symptoms. However, the role of statins, particularly pitavastatin, in modulating serotonin transporter (SERT) function within this context remains underexplored. This study aimed to investigate whether pitavastatin counteracts the neurobiological effects of hypercholesterolemia.

Methods

Low-density lipoprotein receptor knockout (LDLR^-/-) mice on a C57BL/6 background were assigned to three groups: a control group fed a standard chow diet, a group fed a high-fat diet (HFD), and a third group fed a high-fat diet supplemented with pitavastatin (HFD + Pita). We evaluated the effects of HFD with or without pitavasta

SUBMITTER: Chen SJ 

PROVIDER: S-EPMC11330603 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature