The role and mechanism of thrombospondin-4 in pulmonary arterial hypertension associated with congenital heart disease.

ABSTRACT:

Background

Due to a special hemodynamic feature, pulmonary vascular disease in pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) has two stages: reversible and irreversible. So far, the mechanism involved in the transition from reversible to irreversible stage is elusive. Moreover, no recognized and reliable assessments to distinguish these two stages are available. Furthermore, we found that compared with control and reversible PAH, thrombospondin-4 (THBS4) was significantly upregulated in irreversible group by bioinformatic analysis. Hence, we further verify and investigate the expression and role of THBS4 in PAH-CHD.

Methods

We established the monocrotaline plus aorto-cava shunt-induced (MCT-AV) rat model. We measured the expression of THB

SUBMITTER: Zeng H 

PROVIDER: S-EPMC11330619 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature