Metabolomics Profiles Alterations in Cigarette Smokers and Heated Tobacco Product Users.

ABSTRACT:

Background

Heated tobacco products (HTPs) have gained global popularity, but their health risks remain unclear. Therefore, the current study aimed to identify plasma metabolites associated with smoking and HTP use in a large Japanese population to improve health risk assessment.

Methods

Metabolomics data from 9,922 baseline participants of the Tsuruoka Metabolomics Cohort Study (TMCS) were analyzed to determine the association between smoking habits and plasma metabolites. Moreover, alterations in smoking-related metabolites among HTP users were examined based on data obtained from 3,334 participants involved from April 2018 to June 2019 in a follow-up survey.

Results

Our study revealed that cigarette smokers had metabolomics profiles distinct from never smokers, with

SUBMITTER: Harada S 

PROVIDER: S-EPMC11330708 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature