Gender and age differences in the associations between cortical thickness and hand osteoarthritis severity: data from the Osteoarthritis Initiative.

ABSTRACT:

Objective

To evaluate gender differences in the association between metacarpal cortical thickness (T_cort)-a surrogate for bone density-and severity of radiographic hand osteoarthritis (HOA) in a longitudinal observational study.

Method

Hand radiographs of 3575 participants (2039 F/1536 M) from the Osteoarthritis Initiative were assessed at baseline and 48 months. A reader used a semi-automated software tool to calculate T_cort, a measurement of the cortical thickness, for metacarpals 2-4. Average T_cort at baseline and change in T_cort from baseline to 48 months was determined and stratified by gender and age for 7 5-year age groups. Spearman's rank correlation coefficients were calculated for the association of baseline T_cort

SUBMITTER: Smith SE 

PROVIDER: S-EPMC11330735 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature