Extracellular vesicles as mediators of stress response in embryo-maternal communication.

ABSTRACT: Introduction: The pivotal role of extracellular vesicles (EVs) in facilitating effective communication between the embryo and maternal cells during the preimplantation stage of pregnancy has been extensively explored. Nonetheless, inquiries persist regarding the alterations in EV cargo from endometrial cells under stress conditions and its potential to elicit specific stress responses in trophoblast cells. Thus, the aim of this study was to elucidate the involvement of EV miRNA miRNAs in transmitting stress signals from maternal cells to trophoblasts. Methods: The receptive endometrial epithelium analogue RL95-2 cells were subjected to stress induction with 200 µM CoCl₂ for 24 h before EV isolation. JAr trophoblast spheroids, which serve as embryos, were subjected

SUBMITTER: Mousavi SO 

PROVIDER: S-EPMC11330882 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature