Genomic insights into molecular profiling of thymic carcinoma: a narrative review.

ABSTRACT:

Background and objective

Thymic carcinoma is an exceptionally rare cancer, with an annual incidence of just 0.15-0.29 per 100,000 people. Owing to its rarity, only few proven treatments have been developed. Understanding its genetic profile is crucial for the development of targeted therapies. However, limited studies have exclusively examined thymic carcinoma mutations, with most investigation combining thymomas and thymic carcinomas. This paper reviews findings from genetic studies focusing on thymic carcinoma alone and compares them to those of thymoma.

Methods

We conducted a PubMed search for relevant English studies on thymic carcinoma genomics. Then, key papers utilizing target sequencing or whole-exome sequencing were analyzed.

Key content and findings

The most

SUBMITTER: Takata S 

PROVIDER: S-EPMC11330910 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature